Spray-Dried Lactose
نویسندگان
چکیده
pray-dried (SD) lactose was introduced to the pharmaceutical market in the 1960s as an excipient that enables direct compression of formulations in a simple manufacturing process (1). To this day, lactose remains one of the most popular excipients for active pharmaceutical ingredients (APIs) whose dose makes them suitable for direct compression. Several manufacturers make and sell SD lactose, and a pharmaceutical formulator must understand the variables that control performance to select the right grade for an application. This article begins with a description of the structure of SD lactose, followed by a review of the variables that can affect its compressibility, and concludes with a look at a possible next-generation product.
منابع مشابه
PARTIAL CRYSTALLISATION OF LACTOSE IN SPRAY DRYING WAN NUR’AIN NABILA BINTI WAN NAIN A report submitted in partial fulfilment of the requirements for the award of the degree of Bachelor of Chemical Engineering (Bioprocess)
The purpose of this study was to determine the lactose behaviour during partial crystallisation in spray drying. Spray-dried lactose has been widely used in pharmaceutical industries as excipient for dry powder inhalation drugs. Partial crystals of lactose were produced by spray-dried lactose solutions at different operating condition of inlet temperature, feed flow rate and sample concentratio...
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